Solid lipid nanoparticles loading adefovir dipivoxil for antiviral therapy
نویسندگان
چکیده
منابع مشابه
Effect of Hepatitis B Virus Genotypes on the Efficacy of Adefovir Dipivoxil Antiviral Therapy
BACKGROUND Hepatitis B is a common infectious disease in China. Many studies have shown that the genotype of hepatitis B virus (HBV) is probably associated with the efficacy of some antiviral drugs such as interferon α (IFN-α) and Lamivudine (LAM). However, the association between HBV genotype and adefovir dipivoxil (ADV) is controversial. ADV is the most popular antiviral drug in China due to ...
متن کاملDeep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy
BACKGROUND Viral genotype shift in chronic hepatitis B (CHB) patients during antiviral therapy has been reported, but the underlying mechanism remains elusive. METHODS 38 CHB patients treated with ADV for one year were selected for studying genotype shift by both deep sequencing and Sanger sequencing method. RESULTS Sanger sequencing method found that 7.9% patients showed mixed genotype bef...
متن کاملCytotoxicity of pivoxil esters of antiviral acyclic nucleoside phosphonates: adefovir dipivoxil versus adefovir.
Biological effectiveness of antiviral acyclic nucleoside phosphonate adefo vir, 9-[2-(phosphonomethoxy)ethy]ade nine (PMEA) and its more lipophilic (bis)pivaloyloxymethyl ester prodrug adefovir dipivoxil (bis-POM-PMEA) were compared under in vitro conditions in mammalian cell systems. Proliferation of murine splenocytes was inhibited in a concentration-dependent manner, the bis-POM-PMEA being m...
متن کاملeffect of hepatitis b virus genotypes on the efficacy of adefovir dipivoxil antiviral therapy
results genotype b (73.6%) and genotype c (26.4%) were detected in these patients. after treatment for 12 months, the rate of hbv dna seroclearance, alt normalization, and hbeag seroconversion were significantly higher in adv group than in placebo group (p < 0.05). however, there were no significant differences in these three rates between patients infected with genotype b and c (p > 0.05). obj...
متن کاملAntiviral efficacy and pharmacokinetics of oral adefovir dipivoxil in chronically woodchuck hepatitis virus-infected woodchucks.
The antiviral efficacy of orally administered adefovir dipivoxil was evaluated in an 18-week study (12 weeks of treatment and 6 weeks of recovery) conducted with woodchucks chronically infected with woodchuck hepatitis virus (WHV). Adefovir dipivoxil is a prodrug of adefovir designed to enhance its oral bioavailability. Following administration of 15 mg of adefovir dipivoxil per kg of body weig...
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ژورنال
عنوان ژورنال: Journal of Zhejiang University SCIENCE B
سال: 2008
ISSN: 1673-1581,1862-1783
DOI: 10.1631/jzus.b0820047